Opportunity Information: Apply for RFA DA 20 004
The Limited Competition for Adolescent Brain Cognitive Development (ABCD) Study - Coordinating Center (U24 Clinical Trial Not Allowed) is a National Institutes of Health (NIH) cooperative agreement opportunity designed to support a single Coordinating Center for the ABCD Study, a large nationwide research effort following young people over time. The goal of the ABCD Study is to track brain and behavioral development starting in late childhood (around ages 9 to 10) and continuing through adolescence into early adulthood, using a multi-site, multi-modal, longitudinal cohort design. In practical terms, this means the Coordinating Center is expected to play a central organizing role for a complex national project that collects and integrates many types of data across multiple locations over many years, helping ensure that participating sites operate in a consistent, coordinated way.
This opportunity is being issued under the Collaborative Research on Addiction at NIH (CRAN) umbrella and is led by the National Institute on Drug Abuse (NIDA) in partnership with several other NIH Institutes and Centers: the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Mental Health (NIMH), the National Institute on Minority Health and Health Disparities (NIMHD), the National Institute of Neurological Disorders and Stroke (NINDS), the Office of Behavioral and Social Sciences Research (OBSSR), and the National Cancer Institute (NCI). The involvement of multiple NIH components signals that the coordinating infrastructure is meant to support broad, cross-cutting scientific priorities, including substance use and addiction, mental health, neurodevelopment, behavioral and social development, health disparities, and related health outcomes across adolescence and early adulthood.
The mechanism is a U24 cooperative agreement, which typically indicates that NIH expects substantial involvement in the ongoing coordination and oversight of the funded activities rather than a hands-off grant. The listing explicitly notes "Clinical Trial Not Allowed," meaning the award is intended to support coordination and infrastructure for the observational cohort study and its operations rather than initiating or running a clinical trial. Because this is a limited competition, eligibility is restricted; the notice specifies that current primary awardees will be eligible to apply, reflecting the intention to continue the existing ABCD infrastructure with continuity of leadership and operations rather than opening the competition broadly to new organizations.
Operationally, the Coordinating Center supported by this award would be positioned as the hub for a nationwide, multi-site study with multi-modal data collection. While the notice does not enumerate specific tasks, a coordinating center in a study of this scope typically manages cross-site harmonization, common protocols, scheduling and workflow alignment, training and technical assistance, quality assurance and quality control, data coordination, and communication among study sites and NIH program staff. The phrase "prospectively examine brain and behavioral development" underscores that the study follows participants forward in time, which increases the importance of consistent procedures, retention strategies, and standardized data handling across many years and many locations.
The award is structured as one expected award, indicating that NIH planned to fund a single Coordinating Center under this announcement. The new award period is intended to be extended to 7 years in duration, highlighting a long-term commitment to sustaining the national coordinating infrastructure needed for longitudinal follow-up as participants age from late childhood through adolescence and into early adulthood. The opportunity is categorized as discretionary and falls under the broad activity area of education, health, income security, and social services. The eligible applicant type listed is public and state-controlled institutions of higher education, aligning with the academic and research infrastructure typically required to coordinate a large, data-intensive, multi-institutional longitudinal study.
Key administrative details provided include the Funding Opportunity Number RFA DA 20 004, a creation date of April 3, 2019, and an original closing date of July 24, 2019. The CFDA numbers associated with the announcement span multiple NIH programs (93.242, 93.273, 93.279, 93.307, 93.313, 93.399, 93.853, 93.865), reflecting the multi-institute support for the ABCD effort. The award ceiling is listed as 0, which in federal opportunity postings often indicates that a specific cap is not stated in the summary field and that applicants would need to rely on the full announcement for budget expectations and limits. Overall, the opportunity is best understood as a continuation-oriented, limited-competition funding action intended to maintain and operate the central coordinating infrastructure for one of NIH's largest longitudinal studies of adolescent brain and behavioral development.Apply for RFA DA 20 004
- The Department of Health and Human Services, National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Limited Competition for Adolescent Brain Cognitive Development (ABCD) Study - Coordinating Center (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.273, 93.279, 93.307, 93.313, 93.399, 93.853, 93.865.
- This funding opportunity was created on Apr 03, 2019.
- Applicants must submit their applications by Jul 24, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education.
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Frequently Asked Questions (FAQs)
1) What is this funding opportunity?
This is a National Institutes of Health (NIH) cooperative agreement opportunity to support a single Coordinating Center for the Adolescent Brain Cognitive Development (ABCD) Study. The opportunity is titled: "Limited Competition for Adolescent Brain Cognitive Development (ABCD) Study - Coordinating Center (U24 Clinical Trial Not Allowed)."
2) What is the purpose of the ABCD Study?
The ABCD Study is a large, nationwide research effort that follows young people over time to track brain and behavioral development. It begins in late childhood (around ages 9 to 10) and continues through adolescence into early adulthood using a multi-site, multi-modal, longitudinal cohort design.
3) What does "Coordinating Center" mean in this context?
The Coordinating Center is intended to serve as the central hub for organizing and supporting a complex national project conducted across multiple locations over many years. Its role is to help ensure participating sites operate in a consistent and coordinated way for data collection and overall study operations.
4) How many awards does NIH expect to make under this announcement?
NIH expected to fund one award, meaning a single Coordinating Center is planned under this announcement.
5) What is the activity code and what does it imply?
The mechanism is a U24 cooperative agreement. A U24 typically indicates substantial NIH involvement in the ongoing coordination and oversight of the funded activities, rather than a more hands-off relationship.
6) Is a clinical trial allowed under this funding opportunity?
No. The listing explicitly states "Clinical Trial Not Allowed." The intent is to support coordination and infrastructure for an observational longitudinal cohort study and its operations, not to initiate or run a clinical trial.
7) What does "limited competition" mean for applicants?
8) Who is leading this opportunity at NIH?
The opportunity is led by the National Institute on Drug Abuse (NIDA) under the Collaborative Research on Addiction at NIH (CRAN) umbrella.
9) Which other NIH Institutes and Centers are involved?
NIH partners named in the announcement include: the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Mental Health (NIMH), the National Institute on Minority Health and Health Disparities (NIMHD), the National Institute of Neurological Disorders and Stroke (NINDS), the Office of Behavioral and Social Sciences Research (OBSSR), and the National Cancer Institute (NCI).
10) What does multi-institute involvement suggest about the focus of the Coordinating Center?
The involvement of multiple NIH components indicates the coordinating infrastructure is meant to support broad, cross-cutting scientific priorities. These include substance use and addiction, mental health, neurodevelopment, behavioral and social development, health disparities, and related health outcomes across adolescence and early adulthood.
11) What kind of study design is the ABCD Study using?
The ABCD Study is described as a multi-site, multi-modal, longitudinal cohort study. "Longitudinal" and "prospectively examine" indicate participants are followed forward in time across multiple years.
12) What kinds of responsibilities are typically handled by a coordinating center for a study like this?
While the notice does not list specific tasks, a coordinating center for a nationwide, multi-site, multi-modal longitudinal study typically supports cross-site harmonization, common protocols, scheduling and workflow alignment, training and technical assistance, quality assurance and quality control, data coordination, and communication among study sites and NIH program staff.
13) Why is long-term coordination especially important for this project?
Because the study follows participants forward in time from late childhood through adolescence into early adulthood, maintaining consistent procedures and standardized data handling across many years and locations is crucial. Long-term follow-up also increases the importance of coordination that supports retention strategies and consistent operations.
14) What is the expected project period?
The new award period is intended to be extended to 7 years in duration, reflecting a long-term commitment to sustaining national coordinating infrastructure for longitudinal follow-up.
15) What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA DA 20 004.
16) What are the key dates listed for this opportunity?
The creation date is April 3, 2019, and the original closing date is July 24, 2019.
17) What applicant type is listed as eligible?
The eligible applicant type listed is public and state-controlled institutions of higher education, consistent with the academic and research infrastructure often needed to coordinate a large, data-intensive, multi-institutional longitudinal study.
18) What is the CFDA assistance listing information associated with this opportunity?
The CFDA numbers listed are: 93.242, 93.273, 93.279, 93.307, 93.313, 93.399, 93.853, and 93.865. The presence of multiple CFDA numbers reflects support spanning multiple NIH programs and partners.
19) What is the award ceiling for this opportunity?
The award ceiling is listed as 0. In federal opportunity summaries, this often indicates that a specific cap is not stated in the summary field and that budget expectations and any limits would need to be confirmed in the full announcement.
20) How should this opportunity be understood overall?
Based on the information provided, this is best understood as a continuation-oriented, limited-competition funding action intended to maintain and operate the central coordinating infrastructure for one of NIH's largest longitudinal studies of adolescent brain and behavioral development.
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