Opportunity Information: Apply for RFA CA 24 034
This funding opportunity (RFA-CA-24-034) is a National Cancer Institute (NCI) solicitation to support the continued operation of a centralized Network Radiotherapy and Imaging Core Services Center for the NCI National Clinical Trials Network (NCTN). The core purpose is to provide high-level scientific and technical expertise that helps NCTN clinical trials consistently and safely incorporate radiotherapy and imaging-related interventions. In practical terms, the Center is expected to function as a network-wide resource that standardizes and strengthens quality assurance (QA) processes and manages imaging-related data needs so that trial results are reliable, comparable across sites, and suitable for rigorous scientific and regulatory expectations.
A major emphasis of the NOFO is integrated quality assurance and image data management for NCTN trials that use radiotherapy and/or imaging modalities. This includes supporting the technical and operational infrastructure needed to ensure that participating sites deliver radiotherapy according to protocol requirements and that imaging is acquired, handled, and curated in a consistent way. The intent is to reduce variability across institutions, improve protocol compliance, and protect the integrity of trial endpoints that depend on imaging or radiotherapy delivery. Although the announcement does not list every specific task, the scope strongly implies centralized services such as establishing QA standards and workflows, providing expertise to study teams, supporting credentialing or other protocol-driven readiness checks where applicable, and handling the secure intake, organization, and management of imaging datasets and related metadata to make them usable for trial conduct and analysis.
Beyond NCTN, the Center must also have the capacity to extend similar radiotherapy and imaging core services to other approved NCI-supported clinical trial network programs. Examples named in the announcement include NCI Division of Cancer Treatment and Diagnosis (DCTD) early phase clinical trial network activities and the NCI Division of Cancer Prevention (DCP) NCI Community Oncology Research Program (NCORP). This signals that NCI is looking for a core that can operate at scale, serve multiple program contexts, and adapt its support model to different trial phases and network environments while maintaining consistent QA and data management standards.
The award mechanism is a U24 cooperative agreement, meaning NCI expects substantial programmatic involvement with the awardee compared with a standard grant. Cooperative agreements typically come with close coordination, shared governance expectations, and active federal stewardship in areas such as prioritization, performance metrics, and alignment with network-wide trial operations. The NOFO also explicitly states "Clinical Trial Not Allowed," indicating the funded activity is not intended to conduct an independent clinical trial under this award. Instead, the Center supports other NCI-approved trials by providing enabling infrastructure and expertise, rather than acting as the sponsor or operator of a new clinical trial.
From an eligibility standpoint, the opportunity is open to a wide range of domestic applicants, including eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and Indian/Native American Tribal Governments that are not federally recognized. The listing also notes other eligible applicant types such as independent school districts and public housing authorities/Indian housing authorities, along with "others," reflecting a broad eligibility framework typical of NIH opportunities when an organization can credibly perform the required specialized functions. At the same time, there are clear limits on foreign participation: non-domestic (non-U.S.) entities are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply. However, foreign components are allowed as defined in the NIH Grants Policy Statement, which generally means a U.S. applicant can include certain foreign activities or collaborations when justified and permitted under NIH rules, even though the applicant organization itself must be domestic.
Key administrative details include the sponsoring agency (National Institutes of Health, through NCI), the opportunity category (discretionary), and the funding instrument (cooperative agreement). The activity category is listed under education and health, and the relevant CFDA numbers are 93.394 and 93.395. The original closing date is February 24, 2025. The award ceiling is stated as $8,140,000, indicating NCI anticipates a substantial budget consistent with running a national-scale core that supports multiple multi-site trials and networks. The posting record shows a creation date of October 9, 2024.
Overall, the NOFO is aimed at sustaining a specialized, network-level core center that ensures radiotherapy and imaging elements of NCI-supported network trials are executed with consistent quality, and that imaging data are managed in ways that support trial operations and credible outcomes. The Center is positioned as shared infrastructure for NCTN and potentially other NCI trial network programs, with responsibilities centered on standardization, technical support, and coordinated QA and data management rather than initiating new clinical trials.Apply for RFA CA 24 034
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Single Source: NCI National Clinical Trials Network - Network Radiotherapy and Imaging Core Services Center (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394, 93.395.
- This funding opportunity was created on 2024-10-09.
- Applicants must submit their applications by 2025-02-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $8,140,000.00 in funding.
- Eligible applicants include: Independent school districts, Public housing authorities/Indian housing authorities, Others.
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Frequently Asked Questions (FAQs)
What is the funding opportunity number and title?
The opportunity is RFA-CA-24-034. It is an NCI solicitation to support the continued operation of a centralized Network Radiotherapy and Imaging Core Services Center for the NCI National Clinical Trials Network (NCTN).
Which agency is sponsoring this opportunity?
The sponsoring agency is the National Institutes of Health (NIH), through the National Cancer Institute (NCI).
What is the main purpose of this award?
The award supports a centralized, network-wide Core Services Center that provides high-level scientific and technical expertise so NCTN clinical trials can consistently and safely incorporate radiotherapy and imaging-related interventions.
What problem is this Center intended to address?
The Center is intended to reduce variability across institutions, improve protocol compliance, and protect the integrity of trial endpoints that depend on radiotherapy delivery and/or imaging by strengthening standardization, quality assurance (QA), and imaging data management.
What kinds of trials will the Center support?
The Center is designed to support NCTN clinical trials that use radiotherapy and/or imaging modalities, helping ensure results are reliable, comparable across sites, and suitable for rigorous scientific and regulatory expectations.
What is the Center expected to do for radiotherapy and imaging in practical terms?
Based on the NOFO description, the Center is expected to function as a network-wide resource that standardizes and strengthens QA processes and manages imaging-related data needs for NCTN trials.
Is integrated quality assurance and image data management a major emphasis of this NOFO?
Yes. A major emphasis is integrated QA and image data management for NCTN trials using radiotherapy and/or imaging modalities.
What types of quality assurance activities are implied within the scope?
While the announcement does not list every specific task, the scope strongly implies centralized services such as establishing QA standards and workflows, providing radiotherapy/imaging expertise to study teams, supporting credentialing or other protocol-driven readiness checks where applicable, and ensuring participating sites deliver radiotherapy according to protocol requirements.
What types of imaging data services are implied within the scope?
The scope strongly implies secure intake, organization, and management of imaging datasets and related metadata so they can be used effectively for trial conduct and analysis, with consistent acquisition and handling across sites.
Is this Center intended to operate as a network-wide resource?
Yes. The Center is expected to operate as a network-wide resource for the NCTN, supporting consistency and standardization across participating institutions.
Does the NOFO require the Center to support programs beyond NCTN?
Yes. The Center must have capacity to extend similar radiotherapy and imaging core services to other approved NCI-supported clinical trial network programs.
Which non-NCTN programs are specifically named as examples?
The NOFO names examples including NCI Division of Cancer Treatment and Diagnosis (DCTD) early phase clinical trial network activities and the NCI Division of Cancer Prevention (DCP) NCI Community Oncology Research Program (NCORP).
What does it mean that the Center must have capacity to operate at scale?
It indicates NCI is looking for a core that can serve multiple program contexts and network environments, adapt support to different trial phases, and maintain consistent QA and data management standards across those contexts.
What is the award mechanism for this opportunity?
The award mechanism is a U24 cooperative agreement.
What does a U24 cooperative agreement imply about NCI involvement?
A cooperative agreement implies substantial programmatic involvement by NCI compared with a standard grant, including close coordination, shared governance expectations, and active federal stewardship (for example, around prioritization, performance metrics, and alignment with network-wide trial operations).
Is conducting a clinical trial allowed under this award?
No. The NOFO explicitly states "Clinical Trial Not Allowed."
If clinical trials are not allowed, what is funded instead?
The funded activity supports other NCI-approved trials by providing enabling infrastructure and expertise (standardization, QA, and imaging data management), rather than sponsoring or operating an independent clinical trial.
Who is eligible to apply?
Eligibility is broad for domestic applicants and includes (as listed) eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and Indian/Native American Tribal Governments that are not federally recognized. Other eligible applicant types listed include independent school districts, public housing authorities/Indian housing authorities, and "others."
Are non-U.S. (non-domestic) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities are not eligible to apply.
Are non-domestic components of U.S. organizations eligible to apply?
No. Non-domestic components of U.S. organizations are not eligible to apply.
Are foreign components allowed in any form?
Yes. Foreign components are allowed as defined in the NIH Grants Policy Statement, meaning a U.S. applicant may include certain foreign activities or collaborations when justified and permitted under NIH rules, even though the applicant organization must be domestic.
What is the opportunity category and funding instrument?
The opportunity category is discretionary, and the funding instrument is a cooperative agreement.
What is the activity category for this opportunity?
The activity category is listed under education and health.
What CFDA numbers are associated with this opportunity?
The CFDA numbers listed are 93.394 and 93.395.
What is the application closing date?
The original closing date is February 24, 2025.
What is the award ceiling?
The award ceiling is $8,140,000.
When was the posting record created?
The posting record shows a creation date of October 9, 2024.
How does this Center help make trial results more comparable across sites?
By standardizing QA processes, improving protocol compliance for radiotherapy delivery, and ensuring imaging is acquired and curated consistently with appropriate data handling and metadata management, the Center helps reduce inter-institution variability.
What is the overall outcome NCI is trying to achieve with this NOFO?
NCI is aiming to sustain specialized, network-level infrastructure that ensures radiotherapy and imaging elements of NCI-supported network trials are executed with consistent quality and that imaging data are managed to support trial operations and credible outcomes.
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