Opportunity Information: Apply for PAR 17 276
The NIH StrokeNet Regional Coordinating Stroke Centers (U24) opportunity (PAR-17-276) is a National Institute of Neurological Disorders and Stroke (NINDS) cooperative agreement designed to build and sustain the NIH StrokeNet clinical trials network by funding Regional Coordinating Stroke Centers. These regional centers serve as key operational hubs within StrokeNet, helping the network run efficiently and consistently across many participating hospitals and research sites. The broader purpose is to strengthen the national infrastructure needed to develop and execute high-quality, multi-site clinical research that advances stroke prevention, acute treatment, and recovery, with an explicit emphasis on maintaining a balanced trial portfolio across those three domains.
A central theme of the FOA is efficiency and standardization in how stroke trials are launched and delivered across multiple sites. Rather than each study reinventing processes site-by-site, StrokeNet is structured so that trials can be initiated more quickly, conducted with consistent quality controls, and supported by an established system for coordination. The network is intended to support both exploratory early-stage studies (Phase 1/2) and larger confirmatory studies (Phase 3). In addition to therapeutic and prevention trials, the program also supports biomarker-validation studies when they are immediately preparatory to clinical trials, meaning the biomarker work is positioned as a near-term enabler of upcoming interventional or definitive clinical studies rather than as open-ended discovery research.
Within the overall StrokeNet architecture, the FOA makes clear that certain national-level responsibilities are handled by separate, centralized entities: a National Clinical Coordinating Center (NCC) and a National Data Management Center (NDMC). In practical terms, this indicates that Regional Coordinating Stroke Centers are expected to function in alignment with, and in coordination with, these national centers for clinical operations and data systems. The regional centers are therefore part of a larger division of labor where national centers provide core coordinating and data infrastructure, while regional centers organize, support, and manage trial conduct across their regional footprint of enrolling sites.
The award mechanism is a U24 cooperative agreement, which generally signals substantial NIH program involvement compared with a standard grant. Under this structure, the NIH and awardees typically collaborate closely on network activities, performance expectations, and scientific/operational priorities. The activity category is health, and the CFDA listing associated with the opportunity is 93.853, reflecting its alignment with NIH neuroscience and stroke-related research funding.
Eligibility is broad and includes many types of domestic organizations and governmental entities. Eligible applicants span state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (outside of higher education); for-profit organizations (other than small businesses); small businesses; and other entities as further clarified in the FOA. While the list is expansive, the programmatic intent is specifically aimed at currently funded NIH StrokeNet centers and qualified potential new stroke centers capable of serving as Regional Coordinating Stroke Centers within a national clinical trials network.
The FOA was created on May 10, 2017, with an original closing date of September 25, 2017. The anticipated number of awards was 25, and the listed award ceiling was $200,000. The sponsoring agency is the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), through NINDS.
In short, this opportunity supports regional leadership units within NIH StrokeNet to coordinate and enable multi-site stroke clinical trials and trial-ready biomarker validation, emphasizing faster start-up, consistent execution, and high-quality evidence generation across prevention, treatment, and recovery research, while integrating with national clinical and data coordinating centers that handle key network-wide functions.Apply for PAR 17 276
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "NIH StrokeNet Regional Coordinating Stroke Centers (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853.
- This funding opportunity was created on May 10, 2017.
- Applicants must submit their applications by Sep 25, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- The number of recipients for this funding is limited to 25 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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FAQs: NIH StrokeNet Regional Coordinating Stroke Centers (U24) (PAR-17-276)
What is the NIH StrokeNet Regional Coordinating Stroke Centers (U24) opportunity?
It is a National Institute of Neurological Disorders and Stroke (NINDS) funding opportunity that uses a U24 cooperative agreement to build and sustain the NIH StrokeNet clinical trials network by supporting Regional Coordinating Stroke Centers.
What is the funding agency behind this program?
The sponsoring agency is the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), through NINDS.
What does StrokeNet aim to accomplish overall?
The broader purpose is to strengthen national infrastructure for high-quality, multi-site clinical research that advances stroke prevention, acute treatment, and recovery. The program also emphasizes maintaining a balanced trial portfolio across those three domains.
What role do Regional Coordinating Stroke Centers play within NIH StrokeNet?
Regional Coordinating Stroke Centers function as key operational hubs in the network. They help StrokeNet run efficiently and consistently across many participating hospitals and research sites, organizing and supporting trial conduct across a regional footprint of enrolling sites.
Why does the FOA emphasize efficiency and standardization?
The FOA highlights efficiency and standardization so trials can be initiated more quickly and conducted with consistent quality controls across multiple sites, rather than each study creating processes separately at each site.
What kinds of clinical studies is StrokeNet intended to support?
The network is intended to support both exploratory early-stage studies (Phase 1/2) and larger confirmatory studies (Phase 3), covering prevention, acute treatment, and recovery.
Does this program support biomarker studies?
Yes, it supports biomarker-validation studies when they are immediately preparatory to clinical trials. The biomarker work is positioned as a near-term enabler of upcoming interventional or definitive clinical studies, rather than open-ended discovery research.
How do Regional Coordinating Stroke Centers interact with national coordinating entities?
Regional centers are expected to function in alignment with and in coordination with two centralized entities: a National Clinical Coordinating Center (NCC) and a National Data Management Center (NDMC). These national centers handle core coordinating and data infrastructure functions at the network level.
What is the award mechanism and why does it matter?
The mechanism is a U24 cooperative agreement. This generally indicates substantial NIH program involvement compared with a standard grant, with NIH and awardees typically collaborating closely on network activities, performance expectations, and scientific and operational priorities.
What is the activity category for this opportunity?
The activity category is health.
What is the CFDA number associated with this funding opportunity?
The CFDA listing associated with the opportunity is 93.853.
Who is eligible to apply, based on the FOA description provided?
Eligibility is broad and includes many types of domestic organizations and governmental entities, including:
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Other tribal organizations
- Public housing authorities/Indian housing authorities
- Nonprofits with or without 501(c)(3) status (outside of higher education)
- For-profit organizations (other than small businesses)
- Small businesses
- Other entities as further clarified in the FOA
Is the opportunity aimed at any particular type of applicant, even though eligibility is broad?
Yes. The programmatic intent is specifically aimed at currently funded NIH StrokeNet centers and qualified potential new stroke centers capable of serving as Regional Coordinating Stroke Centers within a national clinical trials network.
How many awards were anticipated?
The anticipated number of awards was 25.
What is the listed award ceiling?
The listed award ceiling was $200,000.
When was the FOA created and what was the original closing date?
The FOA was created on May 10, 2017, with an original closing date of September 25, 2017.
What is the FOA identifier referenced for this opportunity?
The opportunity is identified as PAR-17-276 and is titled NIH StrokeNet Regional Coordinating Stroke Centers (U24).
What is the practical “division of labor” described between regional and national components?
The FOA describes a structure where national centers (the NCC and NDMC) provide core clinical operations coordination and data systems infrastructure, while Regional Coordinating Stroke Centers organize, support, and manage trial conduct across their regional enrolling sites.
What problem is StrokeNet designed to solve for multi-site stroke trials?
It is designed to avoid duplicative, site-by-site reinvention of processes by using an established network structure that enables faster trial start-up, consistent execution, and reliable quality control across many participating sites.
What clinical areas are explicitly emphasized for a balanced portfolio?
The FOA explicitly emphasizes balancing the trial portfolio across stroke prevention, acute treatment, and recovery.
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