Addressing the Primary Care Needs of Cancer Survivors (U01 Clinical Trial Required) | RFA CA 23 025

Opportunity Information: Apply for RFA CA 23 025

The National Institutes of Health (NIH) funding opportunity titled "Addressing the Primary Care Needs of Cancer Survivors (U01 Clinical Trial Required)" (Funding Opportunity Number RFA-CA-23-025) is a discretionary grant program offered through a cooperative agreement mechanism (U01). Its central goal is to fund the development and rigorous testing of interventions at the primary care practice level and the broader health system level that can improve the quality of care for adult cancer survivors during active treatment and/or after treatment ends. Because this is a U01 cooperative agreement, awardees should expect substantial NIH involvement during the project, typically including coordination, milestone-driven progress, and collaboration expectations that go beyond a standard investigator-initiated grant. The opportunity is also explicitly structured around clinical trial activity, meaning applicants are expected to design and carry out a study that meets NIH's definition of a clinical trial.

The focus of the program is practical and implementation-oriented: it is aimed at strategies that help primary care settings and health systems better support adult cancer survivors as they transition between oncology and primary care, manage ongoing and late effects of cancer and its treatment, and receive comprehensive, high-quality survivorship care. In real-world terms, this could include improving care coordination between oncologists and primary care clinicians, strengthening survivorship care planning and follow-up workflows, integrating evidence-based screening and management for recurrence risk and secondary cancers, addressing chronic conditions that may be complicated by cancer therapies, and improving systems for monitoring symptoms, mental health, and quality of life. The intent is to move beyond describing survivorship care gaps and instead build and test interventions that can function in routine primary care and health system environments.

A key theme embedded in the announcement is that survivorship care is not solely an oncology responsibility; adult survivors often rely heavily on primary care for long-term management, preventive care, and navigation of complex health needs. This RFA supports interventions that can be implemented where survivors actually receive ongoing care, including community-based primary care practices, integrated delivery systems, and other real-world clinical settings. Projects that address system-level barriers, such as fragmented records, unclear roles across specialties, limited time in visits, inadequate reimbursement structures, or lack of survivorship-specific clinical decision support, align with the spirit of a practice- and health system-level intervention emphasis.

In terms of eligibility, the opportunity is broadly open to a wide range of U.S.-based organizations. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); Native American tribal organizations (other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofits with 501(c)(3) status (and nonprofits without 501(c)(3) status), both outside higher education; for-profit organizations other than small businesses; and small businesses. The announcement also highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and Indian/Native American tribal governments that are not federally recognized.

The geographic and foreign participation rules are strict. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply. In addition, non-domestic components of U.S. organizations are not eligible, and foreign components as defined by the NIH Grants Policy Statement are not allowed. Practically, that means the applicant organization must be U.S.-based and the funded work must be structured without foreign components under NIH policy.

The award information included in the source indicates an award ceiling of $750,000. The original closing date listed for the opportunity was 2023-07-24, and the posting creation date is 2023-03-09. The program is associated with CFDA number 93.393 and falls under the broad activity category of Education and Health. Even though the original due date has passed, the details remain useful as a template for similar NIH survivorship, primary care, and implementation-focused opportunities, especially those using cooperative agreements and requiring clinical trial designs.

Overall, this funding opportunity is designed for teams that can bridge oncology, primary care, and health services research to build interventions that work at the level of practice workflows and health system operations, then test those interventions in a way that produces solid evidence about effectiveness, feasibility, and potential for broader adoption in routine care for adult cancer survivors.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Addressing the Primary Care Needs of Cancer Survivors (U01 Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393.
• This funding opportunity was created on 2023-03-09.
• Applicants must submit their applications by 2023-07-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $750,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA CA 23 025

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